Risk of recurrence of gastrointestinal stromal tumour after surgery: an analysis of pooled population-based cohorts
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Risk of recurrence of gastrointestinal stromal tumour after surgery: an analysis of pooled population-based cohorts.
BACKGROUND The risk of recurrence of gastrointestinal stromal tumour (GIST) after surgery needs to be estimated when considering adjuvant systemic therapy. We assessed prognostic factors of patients with operable GIST, to compare widely used risk-stratification schemes and to develop a new method for risk estimation. METHODS Population-based cohorts of patients diagnosed with operable GIST, w...
متن کاملDefinition and clinical significance of tumour rupture in gastrointestinal stromal tumours of the small intestine.
BACKGROUND Tumour rupture is a risk factor for recurrence of gastrointestinal stromal tumour (GIST). In this study, patterns of recurrence after potential tumour seeding were investigated, and a new definition of tumour rupture, based on major and minor defects of tumour integrity, is proposed. METHODS Patients undergoing surgery for non-metastatic small intestinal GIST from 2000 to 2012 were...
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Introduction: Early recurrence of hepatocellular carcinoma (HCC) is a major risk factor affecting survival even after hepatectomy. Many clinical, biochemical parameters and pathological grading like fibrosis 1 index have been used for risk stratifying HCC. However not many studies have combined all of them. It is therefore important to risk stratify HCC especially with newer PE...
متن کاملPrognostic factors influencing surgical management and outcome of gastrointestinal stromal tumours.
BACKGROUND The purpose of this study was to review surgical experience with gastrointestinal stromal tumours (GISTs) at a single tertiary university hospital, and to identify morphological and genetic prognostic markers of tumour progression. METHODS Forty-eight GISTs from 39 patients were reviewed retrospectively. The prognostic significance of DNA copy number changes, measured by comparativ...
متن کامل[Primary, non-metastatic gastrointestinal stromal tumour surgery: results of the GRISK study].
INTRODUCTION AND OBJECTIVES Radical surgery is the standard treatment for localised gastrointestinal stromal tumours (GIST). A series of primary GIST, their treatment and pre-established risk of recurrence after their follow-up is evaluated. MATERIAL AND METHODS A retrospective, descriptive and multicentre study was conducted on primary, non-metastatic GIST operated on between June 2007 and D...
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